Olanzapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using olanzapine. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Safety and efficacy of Zyprexa and fluoxetine in combination was determined in clinical trials supporting approval of Symbyax fixed dose combination of Zyprexa and fluoxetine. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Increased incidence of stroke or “mini-strokes” called transient ischemic attacks TIAs in elderly people with dementia-related psychosis elderly people who have lost touch with reality due to confusion and memory loss. Zyprexa Relprevv is not approved for these patients. It is not known if Zyprexa will harm your unborn baby. Safety and efficacy of ZYPREXA and fluoxetine in combination was determined in clinical trials supporting approval of Symbyax fixed dose combination of ZYPREXA and fluoxetine.
Patients taking olanzapine should be monitored regularly for worsening of glucose control. Patients starting treatment with olanzapine should undergo fasting blood glucose testing at the beginning of treatment and periodically during treatment. Any patient treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia including polydipsia, polyuria, polyphagia, and weakness. Patients who develop symptoms of hyperglycemia during treatment with atypical antipsychotics should undergo fasting blood glucose testing. The prescriber should be aware that the figures in the tables and tabulations cannot be used to predict the incidence of side effects in the course of usual medical practice where patient characteristics and other factors differ from those that prevailed in the clinical trials. Similarly, the cited frequencies cannot be compared with figures obtained from other clinical investigations involving different treatments, uses, and investigators. The cited figures, however, do provide the prescribing physician with some basis for estimating the relative contribution of drug and nondrug factors to the adverse reaction incidence in the population studied.
Tell your doctor about all the medicines that you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Zyprexa and some medicines may interact with each other and may not work as well, or cause possible serious side effects. Your doctor can tell you if it is safe to take Zyprexa with your other medicines. Do not start or stop any medicine while taking Zyprexa without talking to your doctor first. What should I tell my doctor before taking Zyprexa? Engage the needle safety device. The physician who elects to use Zyprexa for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient.
Some olanzapine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Remove the needle from the vial, holding the vial upright to prevent any loss of material. An increase in mammary gland neoplasms has been found in rodents after chronic administration of other antipsychotic drugs and is considered to be prolactin mediated. Drug Reaction with Eosinophilia and Systemic Symptoms DRESS: DRESS can occur with Zyprexa. Features of DRESS may include rash, fever, swollen glands and other internal organ involvement such as liver, kidney, lung and heart. DRESS is sometimes fatal; therefore, tell your doctor immediately if you experience any of these signs. The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply. The olanzapine orally disintegrating tablet Zyprexa Zydis may contain phenylalanine. Talk to your doctor before using this form of olanzapine if you have phenylketonuria PKU. The most common adverse reactions associated with the immediate-release products were postural hypotension, constipation, weight gain, dizziness, personality disorder, and akathisia. The most common adverse reactions associated with the extended-release IM injection included headache, sedation, weight gain, cough, diarrhea, back pain, nausea, somnolence, dry mouth, nasopharyngitis, increased appetite, and vomiting. Use this medication regularly to get the most benefit from it. To help you remember, mark the days on the calendar when you need to receive the medication. In clinical studies, most adolescents were nonsmokers and this population had a lower average body weight, which resulted in higher average olanzapine exposure compared to adults. High fat levels in your blood cholesterol and triglycerides. High fat levels may happen in people treated with Zyprexa Relprevv, especially in teenagers 13 to 17 years old. Zyprexa Relprevv is not approved in patients less than 18 years old. You may not have any symptoms, so your doctor should do blood tests to check your cholesterol and triglyceride levels before you start taking Zyprexa Relprevv and during treatment. Clinical studies of Zyprexa Relprevv did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In the premarketing clinical studies with oral olanzapine, there was no indication of any different tolerability of olanzapine in elderly patients compared to younger patients with schizophrenia. Oral olanzapine studies in elderly patients with dementia-related psychosis have suggested that there may be a different tolerability profile in this population compared to younger patients with schizophrenia. Elderly patients with dementia-related psychosis treated with olanzapine are at an increased risk of death compared to placebo. When indicated, dose escalation should be performed with caution in these patients. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. If you currently have, or have had any problems in the past with addictive drugs, including street drugs and medication, you should talk with your doctor before you take this medication. You should also mention any serious reactions you may have had to other similar medications. If you are taking other prescription drugs or supplements, you should check with your doctor or pharmacist before taking this drug. It includes a needle and needle safety sheath.
PANSS total score also on the extracted BPRS total on the BPRS psychosis cluster, on the PANSS Negative subscale, and on CGI Severity. Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve right away. Therapeutic Research Faculty 2009. Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. The combined effects of age, smoking, and gender could lead to substantial pharmacokinetic differences in populations. The following adverse reactions have been identified during post-approval use of Zyprexa. Because these reactions are reported voluntarily from a population of uncertain size, it is difficult to reliably estimate their frequency or evaluate a causal relationship to drug exposure. priligy
Do Not Reuse: Medical devices require specific material characteristics to perform as intended. These characteristics have been verified for single use only. Any attempt to re-process the device for subsequent re-use may adversely affect the integrity of the device or lead to deterioration in performance. The magnitude of the impact of this factor is small in comparison to the overall variability between individuals, and therefore dose modification is not routinely recommended. When using Zyprexa and fluoxetine in combination, also refer to the Drug Interactions section of the package insert for Symbyax. Both metabolites lack pharmacological activity at the concentrations observed. The risk of developing tardive dyskinesia and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase. However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses or may even arise after discontinuation of treatment. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away. Dose group differences with respect to prolactin elevation have been observed. Avoid doing things that may cause you to overheat, such as hard work or in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Zyprexa Relprevv must be administered in a registered healthcare facility such as a hospital, clinic, residential treatment center, or community healthcare center with ready access to emergency response services. abov.info endometrin
Zyprexa IntraMuscular olanzapine for injection is intended for intramuscular use only. Close medical supervision and monitoring should continue until the patient recovers. If you experience serious or severe side effects from this medication, you should call your doctor immediately. If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered. Olanzapine is well absorbed and reaches peak concentrations in approximately 6 hours following an oral dose. It is eliminated extensively by first pass metabolism, with approximately 40% of the dose metabolized before reaching the systemic circulation. Food does not affect the rate or extent of olanzapine absorption. Pharmacokinetic studies showed that Zyprexa tablets and Zyprexa ZYDIS olanzapine orally disintegrating tablets dosage forms of olanzapine are bioequivalent. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of olanzapine in children. However, safety and efficacy of olanzapine in children younger than 13 years of age have not been established. This drug may also cause significant gain and a rise in your or levels, especially in teenagers. If you have any questions about Zyprexa Intramuscular, please talk with your doctor, pharmacist, or other health care provider. The resulting solution should appear clear and yellow. Zyprexa IntraMuscular reconstituted with Sterile Water for Injection should be used immediately within 1 hour after reconstitution. Discard any unused portion. Zyprexa is also used to treat moderate to severe manic episodes extremely high mood in adults. It can also be used to prevent the recurrence of these episodes when symptoms come back in adults with bipolar disorder a mental illness with alternating periods of high mood and depression who have responded to an initial course of treatment. Reactions section of the package inserts for these other products. Patients with the following MedDRA terms were counted in this category: hypersomnia, lethargy, sedation, somnolence. BPRS-C total score for patients in the olanzapine treatment group than in the placebo group.
In patients whose manic episode has responded to olanzapine treatment, olanzapine is indicated for the prevention of recurrence in patients with bipolar disorder. Oral carcinogenicity studies were conducted in mice and rats. Zyprexa monotherapy is not indicated for treatment of treatment resistant depression major depressive disorder in patients who do not respond to 2 antidepressants of adequate dose and duration in the current episode. In placebo-controlled trials, there was a significantly higher incidence of cerebrovascular adverse events in patients treated with olanzapine compared to patients treated with placebo. Post-injection Delirium Sedation Syndrome PDSS. Hypodermic Needle-Pro is a registered trademark of Smiths Medical. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. If you notice any of these symptoms in your especially during their first month, tell the doctor right away. Skullcap products are not always what the labels claim. The plants germander and teucrium are often unwanted and unlabeled ingredients in skullcap products. Secondly, you may think you are buying Scuttelaria lateriflora, the species of skullcap that has been studied for medicinal use, but the product may contain a different species of skullcap instead. The most often substituted species are Western Skullcap Scuttelaria canescens Southern Skullcap Scutellaria cordifolia or Marsh Skullcap Scutellaria galericulatum. These species contain different chemicals, so they are not considered interchangeable. How does it work? Keep Zyprexa dry and away from moisture. Engage the needle safety device and remove needle from syringe. Antipsychotic medication paired with a may help you yield a longer lasting, better mental health outcome than treating your condition with medication alone. While medication can be great for controlling associated symptoms, it fails to address behaviors and emotions, and does little to teach a person about what he or she is experiencing. This medication may make you extremely drowsy. Avoid driving, operating heavy machinery, climbing, or other potentially dangerous activities until you find out how this medication affects you. unisom generic when to take
It may also be used in combination with other medication to treat depression. This medication can help to decrease and help you to think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life. ZYPREXA monotherapy is not indicated for the treatment of depressive episodes associated with bipolar I disorder. The tablet will disintegrate quickly in your saliva so that you can easily swallow it with or without drinking liquid. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Patients with the following COSTART terms were counted in this category: buccoglossal syndrome, choreoathetosis, dyskinesia, tardive dyskinesia. Infrequent: amenorrhea 2, breast pain, decreased menstruation, impotence 2, increased menstruation 2, menorrhagia 2, metrorrhagia 2, polyuria 2, urinary frequency, urinary retention, urinary urgency, urination impaired. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Olanzapine has not been evaluated or used to any appreciable extent in patients with a recent history of myocardial infarction or unstable heart disease. Patients with these diagnoses were excluded from premarketing clinical studies. For specific information about the adverse reactions observed with lithium or valproate, refer to the Adverse Reactions section of the package inserts for these other products. walgreens price for sotalol
Zyprexa is usually taken one time each day. The effectiveness of Zyprexa Relprevv in the treatment of schizophrenia is further supported by the established effectiveness of the oral formulation of olanzapine. Efficacy was established in three clinical trials in adult patients with manic or mixed episodes of bipolar I disorder: two 3- to 4-week trials and one monotherapy maintenance trial. Withdraw air to equalize the pressure in the vial by pulling back slightly on the plunger in the syringe. Discard any unused portion of reconstituted Zyprexa IntraMuscular. This medication may contain aspartame.
Talk to the doctor about the risks and benefits of treatment especially when used in teenagers. Concomitant administration of intramuscular olanzapine and parenteral benzodiazepine is not recommended due to the potential for excessive sedation and cardiorespiratory depression. Some MEDICINES MAY INTERACT with Zyprexa Intramuscular. Eli Lilly and Company has received reports of fatality in association with overdose of oral olanzapine alone. Safety and effectiveness of Zyprexa in patients under 13 years of age have not been established. This effect continued until the patient's next scheduled exam, at approximately 20 days after initiation of therapy, at which point olanzapine was discontinued. Fecal incontinence resolved within approximately 24 hours. No organic cause for fecal incontinence was determined, rectal exam was negative, sigmoidoscopy results were normal, and lab tests were all within normal limits. ZYPREXA monotherapy is not indicated for treatment of treatment resistant depression major depressive disorder in patients who do not respond to 2 antidepressants of adequate dose and duration in the current episode. What are some ways to get the most out of my treatment with this medication? Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet. There are no adequate and well-controlled trials with olanzapine in pregnant females. Four pregnancies were observed during clinical trials with Zyprexa Relprevv, including 1 resulting in a normal birth and 3 therapeutic abortions. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Area under the curve achieved after an intramuscular dose is similar to that achieved after oral administration of the same dose. The half-life observed after intramuscular administration is similar to that observed after oral dosing. The pharmacokinetics are linear over the clinical dosing range. Metabolic profiles after intramuscular administration are qualitatively similar to metabolic profiles after oral administration. amaryl gtr
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Of the 2500 patients in premarketing clinical studies with oral olanzapine, 11% 263 were 65 years of age or over. In patients with schizophrenia, there was no indication of any different tolerability of olanzapine in the elderly compared to younger patients. Studies in elderly patients with dementia-related psychosis have suggested that there may be a different tolerability profile in this population compared to younger patients with schizophrenia. Elderly patients with dementia-related psychosis treated with olanzapine are at an increased risk of death compared to placebo. Olanzapine is sometimes used together with other antipsychotic medications or antidepressants. difference between name brand lanoxin and generic
The information below for Zyprexa Relprevv is derived primarily from a clinical trial database consisting of 2058 patients with approximately 1948 patient years of exposure to Zyprexa Relprevv. This database includes safety data from 6 open-label studies and 2 double-blind comparator studies, conducted in patients with schizophrenia or schizoaffective disorder. Additionally, data obtained from patients treated with oral olanzapine are also presented below. Adverse reactions were assessed by the collection of adverse reactions, vital signs, weights, laboratory analytes, ECGs, and the results of physical and ophthalmologic examinations. In the tables and tabulations that follow for Zyprexa Relprevv, the MedDRA terminology has been used to classify reported adverse reactions. Data obtained from oral olanzapine studies was reported using the COSTART and MedDRA dictionaries.
When you leave the clinic, someone must be with you. This drug may make you dizzy or drowsy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid beverages. Do not drive for the rest of the day after receiving your injection. Talk with your doctor before you use medicines that may cause drowsiness eg, sleep aids, muscle relaxers while you are using Zyprexa Intramuscular; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. sibutramine
The longer you use this medication, the greater the possibility that you will develop and neuroleptic malignant syndrome. Tardive dyskinesia is a severe movement condition that affects the lips, tongue, face, torso, and extremities. Neuroleptic malignant syndrome is a rare but deadly condition characterized by high fever, muscle rigidity, and autonomic dysfunction. Zyprexa may cause an increase in blood sugar, particularly when you first start taking this medication. If you begin showing signs of ketoacidosis, a serious condition related to your blood sugar levels, you should call your doctor right away. Symptoms of ketoacidosis include increased thirst or hunger, blurred vision, sweet or fruity smelling breath, weakness, increased urination, and coma. This condition may be fatal.